Cell Chemical Biology
Publications
Selected publications
Representative papers spanning basic mechanistic studies and translational development of p53-targeting strategies.
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Cancer Cell
PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain (Lambert et al.)
PNAS
APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
Nature Communications
Human cancer-associated fibroblasts enhance glutathione levels and antagonise drug-induced prostate cancer cell death
Cell Death & Disease
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5‑Fluorouridine
Cell Death Discovery
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumour cell death
Nature Reviews Clinical Oncology
Therapeutic targeting of TP53 nonsense mutations in cancer
PNAS